Paper - Review

DOI: 10.1002/eji.201344202

Abstract (Only)

(Metagenomic & mechanistic) studies
→ are consistent with → a new model of (periodontal pathogenesis)

Periodontal disease
→ is initiated by 1⃣ synergistic 2⃣ dysbiotic microbial community
→ is NOT ❌ initiated by periopathogens

Low-abundance bacteria
← with community-wide effects
→ are critical → for the development of dysbiosis
→ e.g. Pg.

Integrate
→ the role of Pg. ← with that of other bacteria
→ acting 1⃣ upstream 2⃣ downstream ← in pathogenesis

Accessory pathogens
→ act upstream → to facilitate Pg. colonization
→ co-ordinate metabolic activities

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