Paper - Review

DOI: 10.1038/nature11404

Abstract

LUSC
← lung squamous cell carcinoma
→ a common type of lung cancer
→ causing approx. 400K deaths

❓: Genomic alterations
← in squamous cell lung cancer
→ have NOT ❌ been comprehensively characterized

❓: No molecularly targeted agents
→ have been specifically developed
→ for its treatment

∴ Profile 178 lung squamous cell carcinomas
→ to provide → a comprehensive landscape of 1⃣ genomic 2⃣ epigenomic alterations

The tumor type is characterized
← by complex genomic alterations
← with 1⃣ a mean of 360 exonic mutations 2⃣ 165 genomic rearrangements 3⃣ 323 segments of copy number alterations ← per tumor

❗: Find → statistically recurrent mutations ← in 11 genes
← including mutation of TP53 ← in nearly all specimens

❗: Previously unreported loss-of-function mutations
→ are seen ← in the HLA-A class I major histocompatibility gene

∴ A potential therapeutic target
∴ Offering → new avenues of investigation
→ for the treatment of squamous cell lung cancers

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