Paper - Review

DOI: 10.1038/nmeth.1923

Abstract

Greater throughput → is demanded
← from read aligners
∵ the rate of sequencing increases

The full-text minute index
→ is often used → to make alignment 1⃣ very fast 2⃣ memory-efficient
The approach is ill-suited
→ to finding 1⃣ longer 2⃣ gapped alignment

Bowtie2
→ combines the strengths of the full-text minute index
← with the flexibility & speed of hardware-accelerated dynamic programming algorithms
→ to achieve a combination of high 1⃣ speed 2⃣ sensitivity 3⃣ accuracy

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