Paper - Review

DOI: 10.1038/s41467-021-22890-x

Abstract

❓: The mechanism
← by which anti-cancer immunity shapes early carcinogenesis ← lung adenocarcinoma
→ is unknown

❗: characterize → the immune contexture of 1⃣ invasive lung ADC 2⃣ its precursors
← by 1⃣ transcriptomic immune profiling 2⃣ T cell receptor sequencing 3⃣ multiplex immunofluorescence

❗: Anti-tumor immunity → evolved ← as a continum
← from lung pre-neoplasia to 1⃣ pre-invasive ADC 2⃣ minimally-invasive ADC 3⃣ frankly invasive lung ADC
← with 1⃣ a gradually less effective 2⃣ more intensively regulated immune response
← including 1⃣ down-regulation of immune-activation pathways 2⃣ up-regulation of immuno-suppressive pathways 3⃣ lower infiltration of cytotoxic T cells & anti-tumor helper T cells 4⃣ higher infiltration of regulatory T cells 5⃣ decreased T cell clonality 6⃣ lower frequencies of top T cell clones

1⃣ Driver mutations 2⃣ chromosomal copy number aberrations 3⃣ aberrant DNA methylation
→ may collectively impinge host immune responses
→ facilitate immune invasion
∴ promoting the outgrowth of (fit sub-clones) in pre-neoplasia
→ into dominant clone in invasive ADC

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