Paper - Review

DOI: 10.1038/s41522-020-00181-5

Abstract

Drug repurposing
→ is a feasible strategy
→ for the development of novel therapeutic applications

1⃣ its potential use ← for oral treatments 2⃣ impact ← on host microbiota
→ remain under-explored

Assessed → the influences of topical oral applications ← of (a repurposed FD-approved drug) → thozonium bromide
→ on 1⃣ gastro-intestinal microbiomes 2⃣ host tissues
← in a rat model of dental caries
→ designed to reduce cross-contamination → associated with coprophagy

❗: Recapitulated → the body site microbiota
← that mirrored the human microbiome profile

Oral microbiota → was perturbed
← by the treatments with (specific disruption) ← of 1⃣ Rothia 2⃣ Veillonella
← without affecting (the global composition) ← of the fecal microbiome

Disturbance ← in the oral-gut microbial interactions
→ were identified ← using 1⃣ nestedness 2⃣ machine learning
∴ Increased sharing of (oral taxon) Sutterella ← in the gut microbiota

Caris reduction
← on teeth ← by thonzonium bromide
← without cytotoxic effects
∴ 1⃣ bioactivity 2⃣ biocompatibility ← when used orally
∵ host-tissue analyses

❗: how an oral treatment ← using a repurposed drug
→ causes 1⃣ localized microbial disturbances 2⃣ therapeutic effects
← while promoting turnover of (specific oral species)
← in the lower gut in vivo

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