Paper - Review

DOI: 10.1038/s41522-020-0124-3

Abstract

Oral diseases
← 1⃣ dental caries 2⃣ periodontitis
→ are developed
← when the healthy oral microbiome is imbalanced
∴ the increase of pathobiont strains

Common practice
→ to prevent & treat such diseases
→ is the use of antiseptics
← e.g. chlorhexidine

❓: the impact of these antiseptics
← on 1⃣ the composition 2⃣ metabolic activity ← of the oral microbiome
→ is poorly addressed

Impact of short-term chlorhexidine exposure
→ was explored in-depth
← using two type of oral biofilms

Oral biofilms
← treated with chlorhexidine
→ exhibited → 1⃣ a pattern of inactivation 2⃣ fast re-growth
→ to the initial bacterial concentrations

Chlorehexidine treatment
→ induced profound shifts
← in 1⃣ microbiota composition 2⃣ metabolic activity

Disease
← associated traits
→ were increased

The need → for alternative treatments
← selectively target the disease-associated bacteria ← in the biofilim
← without targeting the commensal micro-organisms

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