Paper - Review

DOI: 10.1038/s41576-019-0171-x

Abstract

Cancer
→ is driven
← by (multiple types) ← of genetic alterations
← which in size → from (point mutations) to (whole-chromosome gains & losses)
∴ Aneuploidy

Chromosome instability
← the process that gives rise to aneuploidy
→ can promote tumorigenesis
← by increasing 1⃣ genetic heterogeneity 2⃣ promoting tumor evolution

How aneuploidy itself contributes
→ to 1⃣ tumor formation 2⃣ tumor progression

❗: some 1⃣ pan-cancer oncogenes 2⃣ tumor suppressor genes
→ drive transformation ← in 1⃣ virtually all cell types 2⃣ cellular contexts
❓: aneuploidy
→ is NOT → a universal promoter of tumorigenesis

Aneuploidy
→ is a 1⃣ context-dependent 2⃣ cancer-type-specific oncogenic event
← that may have (clinical relevance) ← as 1⃣ a prognostic marker 2⃣ a potential therapeutic target

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