Paper - Review

DOI: 10.1038/s41577-020-0306-5

Abstract

The T lymphocyte
← its capacity → for antigen-directed cytotoxicity
→ has become a central focus → for engaging the immune system
← in the fight against cancer

The molecular & cellular biology ← of the T-cell
→ have led → to new strategies in this fight
← including 1⃣ checkpoint blockade 2⃣ adoptive cellular therapy 3⃣ cancer vaccinology

This area of (immunological research)
→ has been highly active ❗ ← for the past 50 years
→ is now enjoying unprecedented bench-to-bedside clinical success

❗: A comprehensive historical & biological perspective
← regarding the advent & clinical implementation ← of (cancer immunotherapeutics)
← with an emphasis on the fundamental importance of T-lymphocyte regulation

❗: Clinical trials
← that demonstrate :1⃣ therapeutic efficacy 2⃣ toxicities ← associated with each class of drug

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