Paper - Review

DOI: 10.1038/s41598-019-55595-9

Abstract

Periodontitis
→ is a prevalent chronic inflammatory disease
∵ The hots response → to oral bacteria
e.g. P. gingivalis

The newer members ← of 1⃣ IL-1 family 2⃣ IL-36s
→ are known → to be involved in host defense → against P. gingivalis
→ are considered ← as key inflammatory mediators ← in chronic diseases

❗: the aim of this study
→ to investigate the potential role of IL-36 ← in periodontitis

∴ IL-36γ mRNA gingival expression is higher ↑ ← in periodontitis patient
∴ 1⃣ IL-36β 2⃣ IL-36Ra mRNA expression is lower ↓ ← compared to healthy controls

Elevated IL-36γ expression ← in patients
→ is positively correlated ← with the RANKL/OPG ratio

IL=36γ expression was induced
→ though TLR2 activation
← ⭕ in primary OEC infected with P. gingivalis
← ❌ not in gingival fibroblast ← the most widespread cell type in gingival connective tissue

Recombinant IL-36γ
→ enhanced the expression of inflammatory cytokines ← of 1⃣ TLR2 2⃣ RANKL/OPG ratio

∴ IL-36γ
→ could be a pivotal inflammatory player ← in periodontitis
← by 1⃣ perpetuating gingival inflammation 2⃣ its associated alveolar bone resorption
→ could be a relevant therapeutic target

---