Paper - Review

DOI: 10.1101/GR.257246.119

Abstract

The identification of (gene fusion)
← from RNA sequencing data
→ is a routine task
← in 1⃣ cancer research 2⃣ precision oncology

❓: Fusion detection
→ remains challenging
← despite the availability of many computational tools

❓: Existing methods
← suffer ← from 1⃣ poor prediction accuracy 2⃣ computationally demanding

❗: Arriba
→ a novel fusion detection algorithm
←with 1⃣ high sensitivity 2⃣ short runtime

❗: Arriba
→ identified a variety of (driver fusions)
← many of which affected druggable proteins

The fusion
→ were significantly associated ← with KRAS wild-type tumors
→ involved proteins ← stimulating the MAPK signaling pathway
∴ They substitute → for activating mutations ← in KRAS

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