Paper - Review

DOI: 10.1101/pdb.prot5384
⚠ ONLY introduction

Identification of active regulatory gene
→ transcriptional control governing biological processes
e.g. cell-type specificity, differentiation, development, proliferation & response

⭐ Mapping DNase I hyper-sensitive (HS) site
→ identifying (all types) (← of regulatory elements)
e.g. promoters, enhancers, silencers, insulators & locus control regions

⭐ DNase-seq
→ high-throughput method
→ identify DNase I HS sites across the whole genome (← by capturing DNase-digested fragments & sequencing)

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