Paper - Review

DOI: 10.1136/gutjnl-2018-315988

Abstract

Objective

❓: The initial colonization ← of the human microbiota
❓: the impact of maternal health ← on neonatal microbiota at birth

❗: to investigate → the possible dysbiosis ← of maternal & neonatal microbiota
← associated → with gestataional diabetes mellitus (GDM)
❗: to estimate → the potential risk of the micirobial shift
→ to neonates

Design

Pregnant women & neonates
← who suffering from GDM
→ were enrolled

581 maternal ← 1⃣ oral 2⃣ intestinal 3⃣ vaginal
248 neonatal ← 1⃣ oral 2⃣ pharyngeal 3⃣ meconium 4⃣ amniotic fluid
→ were collected

The included neonates
→ were predominantly delivered ← by C-section
←with their samples collected within seconds of delivery
→ to avoid → vaginal bacteria contaminations

Results

Numerous & diverse bacterial taxa
→ were identified ← from the neonatal samples

The samples
← from different neonatal body sites
→ were grouped → into distinct clusters

The microbiota
← of 1⃣ pregnant women 2⃣ neonates
→ was remarkably altered ← in GDM
← with a strong correlation ← between 1⃣ discriminatory bacteria 2⃣ the oral glucose tolerance test

Microbes
← varying by the same trend
← across the maternal & neonatal microbiota
→ were observed
∴ The inter-generational concordance of microbial variation
← associated with GDM

1⃣ lower evenness 2⃣ more depletion of KEGG orthologues 3⃣ higher abundance of some viruses
→ were observed ← in the meconium microbiota of neonates
← associated with GDM

Conclusion

GDM
→ can alter the microbiota
← of both 1⃣ pregnant women 2⃣ neonates at birth
→ which sheds light ← on another form of inheritance
→ which highlights the importance ← of understanding the formation of early-life microbiome

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