Paper - Review

DOI: 10.3389/fimmu.2020.00254

Abstract

Maternal stress
→ is a well-established risk factor → for preterm birth
→ has been associated ← with adverse neonatal outcomes ← in the first & subsequent generations
← including (increased susceptibility) → to disease & lasting (immunological changes)

A causal link
← between (prenatal maternal stress) 🆚 (preterm birth)
← as compromised (neonatal immunity)
→ has yet → to be established

1⃣ A murine model ← of (prenatal maternal stress) ← across three generations
2⃣ high-dimensional flow cytometry
→ to evaluate neonatal adaptive immunity

Recurrent prenatal maternal stress
→ induced (preterm birth) ← in the first & second filial generations
→ negatively impacted ← early neonatal growth

❗: Prenatal maternal stress
→ induced → a systematic reduction
← in 1⃣ T-cells 2⃣ B-cells ← as 1⃣ IL-4 2⃣ IL-17A-producing T-cells

Neonatal adaptive immunity
→ gained ↑ resilience
← against (prenatal maternal stress) ← by the third generation

The rate of (prenatal maternal stress-induced preterm birth)
→ can be reduced ← upon cessation of stress
→ through (neonatal growth impairments) persisted

∴ prenatal maternal stress
→ causes (preterm birth)
→ affects (neonatal immunity) ← across generations
→ effects ← that can be ameliorated ← upon cessation

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